Restoring movement through advanced spinal stimulation.

ANEUVO is partnering with healthcare professionals to help people with spinal cord injuries (SCI) live better through ExaStim® Transcutaneous Spinal Stimulation (TSS), an innovative new therapy that helps to improve hand sensation and strength.

Wavelengths
Wavelengths

Introducing the ANEUVO ExaStim® Stimulation System

Evaluated for safety and effectiveness.

ExaStim has been evaluated for safety and effectiveness and has FDA clearance. Clinical studies have shown promising results for people living with spinal cord injuries. ExaStim delivers transcutaneous spinal stimulation through active charge balancing.

Innovative technology. Intuitive operation.

ExaStim is easy to use. As a clinician, you can control therapy through an intuitive, app-based platform on a familiar touchscreen tablet.

Customizable therapy. Powerful results.

Your patients are unique—and their therapy needs are, too. ExaStim Therapy is designed to provide a wide range of highly customizable therapy options.

Spinal stimulation, without surgery.

ExaStim offers your patients the benefits of spinal stimulation without the risks and complications of surgery. For patients, this means no downtime for recovery, and no unnecessary medical procedures to upgrade or replace the device in the future.

Made for movement. Designed for portability.

ExaStim is lightweight, portable, and rechargeable, providing convenient, accessible therapy from any location.

Understanding Spinal Cord Injury (SCI)

Spinal cord injury (SCI) is a life-altering condition that results in partial or complete loss of motor and sensory function below the level of injury. Each year, approximately 18,000 new SCI cases occur in the United States, with an estimated 300,000 individuals living with chronic SCI.1 In Europe, there are an estimated 11,000 new cases per year, with approximately 330,000 people living with SCIs.2 Globally, the World Health Organization estimates that between 250,000 and 500,000 new cases occur each year.3

Despite advances in care, there is currently no curative treatment for SCI. Management focuses on symptom control, prevention of secondary complications, and rehabilitation strategies aimed at optimizing residual function. However, traditional approaches—such as physical therapy, functional electrical stimulation (FES), and pharmacological interventions—have limited efficacy in restoring voluntary movement.

Emerging neuromodulatory techniques, such as transcutaneous spinal stimulation (TSS), offer a promising, non-invasive intervention to enhance neural circuit activation, motor function, and neuroplasticity in individuals with SCI.

Current Standard of Care for SCI Rehabilitation

Some rehabilitation programs use electrical stimulation devices, such as:

  • TENS (Transcutaneous Electrical Nerve Stimulation): Helps with pain relief.
  • FES (Functional Electrical Stimulation) & NMES (Neuromuscular Electrical Stimulation): Cause muscle contractions to help with movement.

However, these devices have limitations:

  • They lack direct spinal circuit engagement needed for voluntary movement.
  • They lack precise targeting for effective recovery.
  • There is limited neuroplasticity induction.
  • They often have limited stimulation options, making them less effective for SCI.

While FES and NMES can improve local muscle activation, their limited impact on spinal circuit excitability restricts their utility in promoting functional recovery in SCI.

Transcutaneous Spinal Stimulation (TSS): A Novel Neuromodulatory Approach

TSS is a non-invasive spinal neuromodulation therapy that delivers pulsed electrical stimulation through surface electrodes placed over the spine. This stimulation engages spinal interneuronal circuits, facilitating voluntary movement, sensory processing, and autonomic function recovery.4

How Does TSS Help with SCI Recovery?

Research shows that TSS helps the nervous system in several important ways:5 6 7

  • Boosting Spinal Activity: “Wakes up” nerve circuits that control movement.
  • Enhancing Nerve Responses: Helps signals travel more effectively, improving
    movement and coordination.
  • Improving Brain-Spinal Cord Communication: Strengthens the connection between
    the brain and spinal cord.
  • Reducing Muscle Stiffness & Pain: Helps ease spasticity and nerve pain.
  • Encouraging Long-Term Nerve Healing: Supports neuroplasticity, the nervous
    system’s ability to rewire itself.

Over time, this therapy may help people with SCI regain movement, improve coordination, and even restore some lost functions like bladder control and blood pressure regulation.

Clinical Implications of TSS for SCI Rehabilitation

  • Improved Motor Function: Enhances voluntary movement, postural control, and coordination.
  • Reduction in Spasticity and Neuropathic Pain: Modifies spinal excitability to mitigate hypertonicity and pain perception.
  • Potential Autonomic Benefits: May contribute to improvements in bladder control, bowel function, and orthostatic regulation.
  • Non-Invasive and Well-Tolerated: A safer, more accessible alternative to epidural spinal stimulation.

Integrating TSS into SCI Recovery: Stages of Implementation

SCI recovery happens in stages, and TSS can help at multiple points in the journey:8

Early Recovery (Days to Weeks After Injury):

While not commonly used at this stage, early stimulation may help keep nerve pathways active for future recovery.

  • May preserve residual spinal excitability and mitigate neurodegeneration.
Rehabilitation Phase (Weeks to Months After Injury):

TSS is most often introduced here, helping activate muscles, reduce stiffness, and improve movement. Many people begin to see meaningful progress in balance and sensation.

  • Enhances motor activation and voluntary movement initiation.
  • Complements task-specific rehabilitation for gait training and upper limb recovery.
  • Reduces spasticity and neuropathic pain, facilitating therapy participation.
Long-Term Recovery (Months to Years After Injury):

TSS is often used long-term to maintain and improve movement, bladder function, and overall well-being. It can also be combined with other therapies, like robotic devices and walking therapy, for better results.

  • Sustains motor recovery and improves functional outcomes when used long-term.
  • Supports autonomic function, potentially aiding bladder, bowel, and cardiovascular regulation.
  • Can be integrated with robotic exoskeletons, gait training, and other rehabilitation modalities.

Advancing SCI Rehabilitation Through TSS

With its growing body of supporting evidence, transcutaneous spinal stimulation represents a paradigm shift in SCI rehabilitation. As research progresses, TSS has the potential to expand treatment possibilities beyond traditional interventions—helping patients achieve greater mobility, independence, and quality of life.

Why is TSS Important for SCI Care?

  • Non-invasive: No surgery or implants required.
  • Safe & well-tolerated: Can be used long-term without major side effects.
  • Accessible & cost-effective: More affordable than invasive options.
  • Supports neuroplasticity: Helps the nervous system rewire itself for lasting improvements.

Support for clinicians.
Peace of mind for their patients.

Contact Us

ANEUVO in the News

ANEUVO has been featured by leading news networks, business and health podcasts, and science and research conferences around the world. Learn more about our company, our technology, and individuals’ experiences with transcutaneous spinal stimulation and the ExaStim Stimulation System in the stories below.

Content Categories

ANEUVO Receives FDA Clearance for ExaStim<sup><sup>®</sup></sup>

ANEUVO Receives FDA Clearance for ExaStim®

U.S. market entry furthers global mission for accessible clinical and at-home non-invasive neuromodulation therapy Los Angeles, CA, April 16, 2026 (GLOBE NEWSWIRE) -- ANEUVO, a...

Read more
ANEUVO Receives FDA Clearance for ExaStim<sup><sup>®</sup></sup>

ANEUVO Receives FDA Clearance for ExaStim®

U.S. market entry furthers global mission for accessible clinical and at-home non-invasive neuromodulation therapy Los Angeles, CA, April 16, 2026 (GLOBE NEWSWIRE) -- ANEUVO, a...

Read more
Investigational therapy helps Easthampton man regain movement after spinal cord injury

Investigational therapy helps Easthampton man regain movement after spinal cord injury

EASTHAMPTON, MA (WGGB/WSHM) -- Nearly a decade after a training ride crash left him with a spinal cord injury, an Easthampton man is regaining function...

Read more
ANEUVO Secures Series C Funding to Strengthen ExaStim<sup>®</sup> Regulatory Readiness and Global Operational Scale

ANEUVO Secures Series C Funding to Strengthen ExaStim® Regulatory Readiness and Global Operational Scale

Proceeds to support manufacturing growth, regulatory advancement, and disciplined commercialization expansion Los Angeles, CA, March 05, 2026 (GLOBE NEWSWIRE) -- ANEUVO, a medical technology company...

Read more
ANEUVO Recognized with Taiwan’s 22nd National Innovation Award for ExaStim<sup>®</sup> Neuromodulation Technology

ANEUVO Recognized with Taiwan’s 22nd National Innovation Award for ExaStim® Neuromodulation Technology

Honor highlights international startup advancing non-invasive rehabilitation technology for people living with chronic spinal cord injury Los Angeles, CA, Feb. 11, 2026 (GLOBE NEWSWIRE) --...

Read more
ANEUVO Showcases ExaStim<sup>®</sup> Therapy At RehaCare 2025 and ISCoS 2025

ANEUVO Showcases ExaStim® Therapy At RehaCare 2025 and ISCoS 2025

The first MDR-Approved Non-Invasive Spinal Stimulation System in Europe Los Angeles, CA, Sept. 16, 2025 (GLOBE NEWSWIRE) -- ANEUVO today announced its participation in two...

Read more
ANEUVO’s ExaStim<sup>®</sup> Earns CE Mark Certification

ANEUVO’s ExaStim® Earns CE Mark Certification

Key Milestone Signals Readiness for European Market Entry and Commitment to Quality Los Angeles, CA, April 09, 2025 (GLOBE NEWSWIRE) -- ANEUVO, a pioneer in...

Read more
ANEUVO Launches ASPIRE<sup>™</sup> Home Study to Evaluate Home Use of ExaStim<sup>®</sup>

ANEUVO Launches ASPIRE™ Home Study to Evaluate Home Use of ExaStim®

This new phase of clinical research will test the safety and feasibility of ANEUVO’s non-invasive therapy for future use by individuals living with chronic spinal...

Read more
View More

[1] Council of Europe Parliamentary Assembly (PACE). “Disability and Social Inclusion.” Available at: https://pace.coe.int/files/9680/html

[2] World Health Organization (WHO). (n.d.). Spinal cord injury fact sheet. Retrieved from https://www.who.int/news-room/fact-sheets/detail/spinal-cord-injury

[3] Christopher & Dana Reeve Foundation. (n.d.). Statistics about paralysis. Retrieved from https://www.christopherreeve.org/todays-care/paralysis-help-overview/stats-about-paralysis

[4] Taylor C, McHugh C, Mockler D, Minogue C, Reilly RB, Fleming N. (2021) Transcutaneous spinal cord stimulation and motor responses in individuals with spinal cord injury: A methodological review. PLoS One. 2021 Nov 18;16(11): e0260166.

[5] Gerasimenko, Y., Sayenko, D., Gad, P., & Edgerton, V. R. (2021). Transcutaneous spinal cord stimulation: Advances in mechanisms and clinical applications for spinal cord injury rehabilitation. Frontiers in Cellular Neuroscience, 15, 1095259.

[6] Zhu, M., Wei, Y., Xiang, X., & Li, Y. (2022). The application of transcutaneous spinal cord stimulation in improving movement function after spinal cord injury: A review. Neural Plasticity, 9267622.

[7] Benavides, F. D., Jo, H., Li, X., & Contreras-Vidal, J. L. (2021). The role of transcutaneous spinal cord stimulation in motor recovery after spinal cord injury: A systematic review. Biomedical Journal, 11(8).

[8] Shi C, Chen Y, Ye L, Feng J, Dong G, Lu S. (2024). Transcutaneous spinal cord stimulation on motor function in patients with spinal cord injury: A meta-analysis. NeuroRehabilitation, 54(4):563-573.